cliffordfosterr
Guest
Dec 10, 2024
2:00 AM
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Kamagra is a medication containing sildenafil citrate, the same active ingredient as in Viagra. It is primarily used to treat erectile dysfunction by improving blood flow to the penis. Here's an overview of how the body metabolizes Kamagra:
1. Absorption
After oral administration, Kamagra is absorbed through the gastrointestinal tract.
Peak plasma concentrations are typically reached within 30 to 120 minutes, depending on factors like food intake (a high-fat meal can delay absorption).
2. Distribution
Sildenafil is distributed throughout the body's tissues, binding to plasma proteins at a rate of approximately 96%.
3. Mechanism of Action
Sildenafil works by inhibiting phosphodiesterase type 5 (PDE5), an enzyme that breaks down cyclic guanosine monophosphate (cGMP).
Increased cGMP levels in the smooth muscles of the blood vessels lead to relaxation and improved blood flow, specifically in the corpus cavernosum of the penis.
4. Metabolism
Sildenafil is metabolized predominantly in the liver by the cytochrome P450 enzymes CYP3A4 and CYP2C9.
It is broken down into active metabolites, which contribute to its effects but are less potent than sildenafil itself.
5. Excretion
The drug and its metabolites are excreted mainly through feces (approximately 80%) and urine (approximately 13%).
The terminal half-life of sildenafil is about 3 to 5 hours, meaning the effects diminish significantly after this period.
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